The symptoms of hyperparathyroidism include

Symptoms depend on whether the hyperparathyroidism is the result of parathyroid overactivity or secondary. In primary hyperparathyroidism, about 75% of people have no symptoms. The problem is often picked up incidentally during blood work for other reasons, and the test results show a higher amount of calcium in the blood than normal.Many other people only have non-specific symptoms. Symptoms directly due to hypercalcemia are relatively rare, being more common in patients with malignant hypercalcemia. If present, common manifestations of hypercalcemia include weakness and fatigue, depression, bone pain, muscle soreness (myalgias), decreased appetite, feelings of nausea and vomiting, constipation, polyuria, polydipsia, cognitive impairment, kidney stones and osteopenia or osteoporosis. A history of acquired racquet nails (brachyonychia) may be indicative of bone resorption.Parathyroid adenomas are very rarely detectable on clinical examination. Surgical removal of a parathyroid tumor eliminates the symptoms in most patients. In secondary hyperparathyroidism, the parathyroid gland is behaving normally; clinical problems are due to bone resorption and manifest as bone syndromes such as rickets, osteomalacia, and renal osteodystrophy. Ref ganong's review of medical physiology 25e