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Surgery General 8d9454d0

The following statements regarding streptokinase are true, except:

A
It is a protein produced by streptococci.
B
Its complex with plasminogen is inhibited by aIpha2-anti plasmin.
C
It may rarely produce anaphylaxis
D
It is initially given as a loading dose.
High-Yield Explanation
Streptokinase is a 47-kDa protein produced by beta-hemolytic streptococci. It forms a stable complex with plasminogen, which is not inhibited by antiplasmih. A large loading dose is given intravenously to overcome antibodies that may be formed from prior streptococcal infections. Being a foreign protein it may rarely cause anaphylaxis.

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