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Pharmacology Epilepsy 8d41170a

If carbamazepine is added to valproate, which side effect of valproate can increase?

A
Thrombocytopenia
B
Hepatotoxicity
C
Hyperammonemia
D
Pancreatitis
High-Yield Explanation
Valproate is metabolized by cytochrome P450 and produce a metabolite which is hepatotoxic Carbamazepine is enzyme inducer which cause the induction of its metabolism and produce more metabolite, thus causing hepatotoxicity

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