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A 72-year-old man is newly diagnosed with bullous pemphigoid. Which of the following is the most appropriate next step in the management?

A
plasmapheresis
B
low-dose prednisone (10-20 mg/day)
C
high-dose prednisone (50-100 mg/day)
D
azathioprine (150 mg/day)
High-Yield Explanation
Severe cases require systemic steroids, often with the addition of azathioprine. Dapsone is useful in mild cases, and occasionally in very mild cases (or for local recurrences) topical glucocorticoid therapy will suffice.

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