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General Medicine General 8d0b17d7

A 68 year old woman was admitted with a history of weakness for two months. On examination, cervical lymph nodes were found enlarged and spleen was palpable 2 cm below the costal margin. Her hemoglobin was 10.5 g/dl, platelet count 27 x 109/L and total leukocyte count 40 x 109/L, which included 80 % mature lymphoid cells with coarse clumped chromatin. Bone marrow revealed a nodular lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD19, CD5, CD20 and CD23 and were negative for CD79B and FMC-7. The histopathological examination of the lymph node in this patient will most likely exhibit effacement of lymph node architecture by?

A
A monomorphic lymphoid proliferation with admixed proliferation centers
B
A polymorphous population of lymphocytes, plasma cells, eosinophils and scattered large binucleated cells
C
A predominantly follicular pattern with variably-sized follicles effacing nodal architecture
D
A diffuse proliferation of medium to large lymphoid cells with high mitotic rate.

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