The hyperkinetic features of the Huntington's disease are due to the loss of

It is a genetic disease of nervous system inherited as an autosomal dominant disorder usually occurring between 30 and 50 years of age. Site of lesion : There occurs damage to GABAergic and cholinergic neurons of striatum (caudate and putamen ) that project to pallidum The loss of GABAergic pathway to the external pallidum releases inhibition, permitting the hyperkinetic features of the disease to develop. It affects 5 out of 100,000 people worldwide Ref: Ganong's Review of Medical Physiology 26th edition pg no.566