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The oxygen hemoglobin dissociation curve is sigmoid because:

A

Binding of one oxygen molecule increases the affinity of binding other 0, molecules

B

Binding of one oxygen molecule decrease the affinity of binding other 02 molecules

C

Oxygen affinity of Hemoglobin decreases when the pH of blood falls

D

Binding of oxygen to hemoglobin reduces the affinity of Hb for CO2

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