The therapeutic efficacy of antihypeensive drug is blunted by NSAIDs because they:

Ans. is 'd' i.e., Decrease the synthesis of vascular prostacyclin o NSA IDs blunt the antihypeensive effect of diuretics. o Loop diuretics act paly (intrarenal hemodynamics) by increasing the synthesis of prostaglandins by stimulation of COX o Prostaglandins (especially PGE2 and PGI2) cause renal vasodilation, natriuresis and increased water clearance due to inhibition of the ADH action. o NSAIDs inhibit the synthesis of prostaglandins by inhibiting COX. Therefore, NSAIDs blunt the diuretic effect of loop diuretics.