Pediatrics C.V.S. 8ce83fe1 vWF protects: A Factor V B Factor VI C Factor VII D Factor VIII High-Yield Explanation d. Factor VIII(Ref: Nelson's 20/e p 2390, Ghai 8/e p 349)2 major functions of vWF are: Platelet adhesion via Gp Ib/IX and stabilization of factor VIII in circulation.