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Pathology General 8c9602e1

Pelger Huet anamoly shows presence of ?

A
Hyposegmented neutrophil
B
Hypersegmented neutrophil
C
Unsegmented neutrophil
D
None of the above
High-Yield Explanation
Ans. is 'a' i.e., Hyposegmented neutrophil Pelger Huet anomaly It is a genetic disorder with an autosomal dominant inheritance pattern. It is a blood laminopathy associated with the lamin B receptor. It is characterized by a white blood cell type known as a neutrophil whose nucleus is hyposegmented. Heterozygotes are clinically normal, although their neutrophils may be mistaken for immature cells, which may cause mistreatment in a clinical setting. Homozygotes tend to have neutrophils with rounded nuclei that do have some functional problems.

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