Social & Preventive Medicine General 8c49ef42 Drug of choice for treatment of leptospirosis is: A Penicillin B Ampicillin C Tetracycline D Doxycycline High-Yield Explanation Penicillin is the drug of choice for treatment of leptospirosis. Other drugs used are tetracycline and doxycycline. Ref: Park 21st edition, page 267.