What is the most likely diagnosis of this penile lesion found in a 54-year-old man with lymphadenopathy and weight loss?

Answer A. Squamous-cell carcinomaSquamous-cell carcinoma is the correct answer. Human papillomavirus (HPV) is a common risk factor for squamous-cell carcinoma of the penis, as is the case here. HPV can also cause cervical cancer in women. The presence of metastasis to the inguinal lymph nodes is a poor prognostic factor for survival. Primary prevention, education, and vaccination are important to reduce the occurrence of HPV infection and its associated cancers.