In which of the following diseases decrease in levels of single neurotransmitter was first identified?
High-Yield Explanation
Neurons of the substantia nigra communicate with neurons of the basal ganglia by liberating the neurotransmitter dopamine (DA). In Parkinson's disease, neurons of the substantia nigra progressively degeneration; as a result, the amount of DA available for neurotransmission in the corpus striatum is lowered. Ref Harrison20th edition pg 2456