Lewis triple response is mediated by

The three-pa response--the red reaction, wheal, and flare--is called the triple response and is pa of the normal reaction to injury. The flare is absent in locally anesthetized skin and in the denervated skin after the sensory nerves have degenerated, but it is present immediately after nerve block or section above the site of the injury. This, plus other evidence, indicates that it is due to an axon reflex, a response in which impulses initiated in sensory nerves by the injury are relayed antidromically down other branches of the sensory nerve fibersRef: Ganong&;s Review of Medical Physiology 25th Edition. Page: 613