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Pathology JIPMER 2017 89fbba6d

Loss of 'Y' chromosome is associated with which of the following types of renal cell carcinoma (RCC)?

A
Clear cell RCC
B
Papillary RCC
C
Chromophobe RCC
D
Collecting duct RCC
High-Yield Explanation
Papillary RCC accounts for 10% to 15% of renal cancers. It is characterized by a papillary growth pattern. The most common cytogenetic abnormalities are:- Trisomies 7 and 17 Loss of Y in male patients in the sporadic form Trisomy 7 in the familial form. These tumors are not associated with 3p deletions.

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