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Pathology General pathology 89a90a91

Which is true regarding IL-1?

A
Mainly derived from neutrophils
B
Produces necrosis of tumor cells
C
Increases expression of MHC coded proteins
D
Upregulates adhesion molecules
High-Yield Explanation
Produced by tissue macrophages, monocytes, fibroblasts and dendritic cells and also expressed by B cells, lymphocytes, NK cells and epithelial cells Increases the expression of adhesion factors on endothelial cells to enable transmigration Causes fever, hyperalgesia, vasodilation and hypotension

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