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Pathology Genetic Basics Of Carcinogenesis 89a7a190

Which of the following is not true about PTEN gene?

A
It is the membrane associated phosphatase
B
Encoded by gene located on chromosome 10q23
C
It is mutated in endometrial, breast, thyroid carcinoma
D
It acts as a proto-oncogene
High-Yield Explanation
PTEN (phosphatase and tensin homologue) Membrane-associated phosphatase encoded by a gene on chromosome 10q23 that is mutated in Cowden syndrome Autosomal dominant disorder C/F:- Marked by frequent benign growths, such as skin appendage tumors Increased incidence of epithelial cancers, paicularly of the breast, endometrium, and thyroid. PTEN acts as a tumor suppressor by serving as a brake on the PI3K/AKT arm of the receptor tyrosine kinase pathway. PTEN gene function is lost in many cancers through deletion, deleterious point mutations, or epigenetic silencing.

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