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Pathology All India exam 8905a1c7

Which of the following is true about Tetralogy of Fallot?

A
Cyanosis is often present in the first few days of life
B
There is a right sided aoic arch in about 50% of cases
C
The murmur becomes so er during a cyano c spell as flow through the pulmonary valve is increased
D
There is an association with DiGeorge syndrome
High-Yield Explanation
There is an associa on with DiGeorge syndrome. Tetralogy of Fallot is the most common congenital cyano c hea condition. It may present with cyanosis in the first few days of life, though this is rare. Usually, it presents as a murmur detected in first few months of life or as hypercyano c spells in late infancy. A hot bath will increase cyanosis, as the vasodilator on results in a decrease in the peripheral vascular resistance, and so the flow through the pulmonary aery decreases, and cyanosis increases. During a cyano c spell the decrease (not increase) in flow through the pulmonary aery results in the murmur becoming so er or inaudible. There is a right-sided aor c arch in about 30% of cases.

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