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Pharmacology Anti-Emetic 88c6edee

Drug given for metoclopramide induced dystonic reaction is:

A
Pheniramine
B
Promethazine
C
Chlorpromazine
D
Prochlorperazine
High-Yield Explanation
Ans. (B) Promethazine(Ref: KDT 8th/e p180)"Acute muscle dystonia caused by antiemetic-antipsychotic drugs is promptly relieved by parenteral promethazine or hydroxyzine" This is based on central anti-cholinergic action of the drugs.Promethazine is a first generation anti-histaminic which has maximum penetration of blood brain barrier and maximum anticholinergic activity.

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