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Pharmacology Adverse Drug Effect 8860436b

Cholelithiasis and choledocholithiasis is caused by?

A
Clofibrate
B
Chloramphenicol
C
Cotrimaxozole
D
NS AIDS
High-Yield Explanation
ANSWER: (A) ClofibrateREF: Robbin's 8th ed CH: 8Drugs causing cholelithiasis and choledocholithiasis:Clofibrates: Clofibrate, used to lower blood cholesterol, increases hepatic HMG-CoA reductase and decreases conversion of cholesterol to bile acids by reducing cholesterol 7-a-hydroxylase activity. The net result of these influences is excess biliary secretion of cholesterolEstrogen and OOP'SSomatostatin analogues appear to predispose to gallstones by decreasing gallbladder emptying.Ampicillin

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