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Ans. is 'b' i.e., Folic acid o Folic acid supplementation decreases the incidence and recurrence of neural tube defects (NTD). Because the neural tube closes within the 1st 28 days ofconception, periconceptional supplementation is needed for prevention. It is recommended that women without a prior history of a NTD, ingest 400 ?g/day throughout their reproductive years. Women with a history of a prior pregnancy complicated by a NTD or a Ist-degree relative with a NTD should have preconceptual counseling and they should ingest 4 mgfday of supplemental folic acid at least 1 mo before conception. Use of some antiepileptic drugs (valproatet carbamazepine) during pregnancy is associated with an increased risk of NTD. Women taking these medications should ingest 1-5 mg of folic acid/day in the preconception period.