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Biochemistry General 8717dd84

Which of the following are intracellular events occurring in fibroblast during synthesis of collagen-

A
Hydrolysis of procollagen to collagen
B
Glycosylation of proline
C
Formation of triple helix
D
Formation of covalent cross link b/w fibrils
High-Yield Explanation
Formation of triple helix (of pre-a-chains) takes place intracellularly in RER. Formation of a cross-link between fibrils (i.e. self-assembly of tropocollagen monomers into mature collagen fiber) occurs extracellularly after secretion from fibroblasts. Glycosylation also occurs intracellularly, but its glycosylation of hydroxylysine (not of proline).

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