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Pediatrics Coagulation disorders 865b56bd

The coagulation profile in a 13 year old girl with Menorrhagia having von Willebrands disease is:

A
Isolated prolonged aPTT with a normal PT
B
Isolated prolonged PT with a normal aPTT
C
Prolongation of both PT and aPTT
D
Prolongation of thrombin time
High-Yield Explanation
- Von Willebrand factor acts as a plasma carrier of factor VIII and circulates in blood as factor VIII-VWF complex. - Thus, VWF deficiency impairs intrinsic pathway of coagulation & prolongs aPTT - Extrinsic pathway of coagulation remains unimpaired, PT is not altered.

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