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Pharmacology General 86300e22

Which is not a 2nd generation anti–histaminic agent ?

A
Cetirizine
B
Cyclizine
C
Loratadine
D
Fexofenadine
High-Yield Explanation
Antihistaminics may be classified into the first generation and the second generation compounds on the basis of CNS penetration and anticholinergic properties. First Generation Anti-histaminics can penetrate the blood-brain barrier and possess additional anticholinergic properties which are lacking in second-generation drugs. Cyclizine is the first generation whereas cetirizine, loratadine and fexofenadine are second generation drugs.

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