Meera is a 43-year-old woman with a body mass index (BMI) of 32. She presented with abnormal uterine bleeding to her gynecologist, who performed an endometrial biopsy that indicated endometrial cancer, specifically endometrial adenocarcinoma of endometrioid histology.Meera's family history is significant for colon cancer. Her mother was diagnosed with colon cancer at age 66. Her paternal aunt was diagnosed with endometrial cancer at age 67. Suspecting hereditary disease which of the following DNA repair mechanism is defective in Meera?