The principal polypeptide that increases food intake are the following, EXCEPT:

The major afferent signal allowing the brain to sense the level of energy stores is the hormone leptin. Circulating leptin levels are propoionate to the amount of body fat. Higher circulating leptin levels generally reduce, while lower levels generally increase, appetite. Factors that increases the appetite: Neuropeptide Y Melanin-concentrating hormone Agouti-related peptide Orexin Endocannabinoid Ref: Paulsen D.F. (2010). Chapter 6. Adipose Tissue. In D.F. Paulsen (Ed), Histology & Cell Biology: Examination & Board Review, 5e.