Unknown General 85283059 Significant weight loss is - A 5% over 6-12 months B 10% over 6-12 months C 5% over 6 weeks D 10% over 6 weeks High-Yield Explanation Ans. is 'a' i.e., 5% over 6-12 months o Clinically important weight loss is defined as the loss of 10 pounds (4.5 kg) or < 5% of one's body weight over a period of 6-12 months.