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Pharmacology Autonomic nervous system 848cf953

Which of the following drug does not cross the blood-placental barrier?

A
Atropine
B
Glycopyrolate
C
Physostigmine
D
Hyoscine hydro bromide
High-Yield Explanation
Ref:KD Tripathi pharmacology 7th edition (page.no: 19,116) Placental membranes are lipoidal and allow free passage of lipophilic drugs while restricting hydrophilic drugs. Glycopyrrolate is a quaternary ammonium compound. So it can't cross placenta and brain(BBB). Other drugs can cross the placenta

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