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Pharmacology General Pharmacology 8418e5c2

True statement regarding first order kinetics is:

A
Rate of elimination is independent of plasma concentration
B
A constant proportion of plasma concentration is eliminated per unit time
C
Half life increases with dose
D
Clearance decreases with dose
High-Yield Explanation
Ans. (B) A constant proportion of plasma concentration is eliminated per unit time(Ref: RID 8th/e p38-39)In first order kinetics, rate of elimination is proportional to plasma concentration of the drug. Half life and clearance are constant in first order kinetics.

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