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Medicine C.N.S 8408cef5

Which of the following dopamine agonists used in treatment of parkinsonism is available as a transdermal patch but not oral formulation?

A
Apomorphine
B
Ropinirole
C
Rotigotine
D
Pramipexole
High-Yield Explanation
Both ropinirole and pramipexole are available as orally administered immediate (tid) and extended-release (qd) formulations. Rotigotine is administered as a once-daily transdermal patch, and may be useful in managing surgical patients who are NPO. Apomorphine is a dopamine agonist with efficacy comparable to levodopa, but it must be administered parenterally as it is rapidly and extensively metabolized if taken orally. Ref harrison 20th edition page 3127

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