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Pharmacology Endocrinology 83abaee5

Bisphosphonates act by

A
Increasing the osteoid formation
B
Increasing the mineralization of osteoid
C
Decreasing the osteoclast mediated resorption of bone
D
Decreasing the parathyroid hormone secretion
High-Yield Explanation
Bisphosphonates (BPNs) are analogues of pyrophosphate: carbon atom replacing oxygen in the P-0-P skeleton. They inhibit bone resorption by inhibiting osteoclast function- useful to prevent osteoporosis in addition to metabolic bone diseases and hypercalcaemia. (REF.Essentials of Pharmacology TD TRIPATHI 6th EDITION page no 333)
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