The therapeutic advantage that pencillin V has over pencillin G is:

ACID-RESISTANT  ALTERNATIVE  TO PENICILLIN-G  Phenoxymethyl penicillin (Penicillin V)  It differs from PnG only in that it is acid stable. Oral absorption is better; peak blood level is reached in 1 hour and plasma  t½  is 30-60 minutes. The antibacterial spectrum of penicillin V is identical to PnG, but it is about 1/5 as active against Neisseria, other gram negative bacteria and anaerobes.