Which of the following is not true about bosentan -

Ans. is 'b' i.e., used in malignant hepatitisEndothelin receptor antagonistso There are two endothelin receptor subtypes - ETA and and ETB.o Bosentan is a nonselective endothelin antagonist - blocks both ETA and ETB.o Bosentan is active intravenously and orally.o Bosentan is currently approved for use in pulmonary hypertension.o Tezosentan another nonseiective antagonist is used investigation for the treatment of acute heart failure,o Sitaxentan and ambrisentan are selective ETA,( antagonists.o Phosphoramidon inhibits formation of endothelin by inhibiting endothelin converting enzyme.Remembero Bosentan can cause severe hepatotoxicity - monthly liver function tests should be done,o It is contraindicated in pregnancy.