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Pharmacology C.N.S 82abafc3

The recently approved antiepileptic drug lacosamide acts by:

A
Inhibiting synaptic vesicular protein
B
Inhibing CRMP protine
C
Inhibing GABA metabolism
D
Inhibing glutamate release
High-Yield Explanation
(Ref: Katzung, 14th ed. pg. 417)* CRMP is Collapsing Response Mediator Protein, which causes neuronal excitotoxicity by releasing BDNF (Brain Derived Neurotropic Factor).* The drug Lacosamide acts by inhibiting CRMP protein, thereby causing protective action against neuronal excitotoxicity.

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