A number of structural chromosome abnormalities are seen clinically. No loss of genetic material occurs in:

These occur when there are two breaks in the same chromosome, and the intervening genetic material is inveed before the breaks are repaired. Although no genetic material is lost or duplicated, the rearrangement may alter gene function. Ref: Cunningham F.G., Leveno K.J., Bloom S.L., Hauth J.C., Rouse D.J., Spong C.Y. (2010). Chapter 12. Genetics. In F.G. Cunningham, K.J. Leveno, S.L. Bloom, J.C. Hauth, D.J. Rouse, C.Y. Spong (Eds), Williams Obstetrics, 23e.