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Medicine Immunology and Rheumatology 826124e1

Which is the best treatment in a case of PNH presenting with black colour urine?

A
Eculizumab
B
Rituximab
C
Infliximab
D
Prednisolone
High-Yield Explanation
Ans. D. PrednisoloneTreatment:Best Initial treatment to control Hemolysis = PrednisoloneBest treatment = BMTBest treatment to prevent chronic hemolysis or clot formation = Eculizumab:Eculizumab is a monoclonal antibody that specifically binds to the complement protein C5, thus inhibiting terminal complement mediated intravascular hemolysis in PNH patients.

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