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Pathology Cellular Pathology 822b83e3

Which of these is not responsible for removal of free radicals?

A
Catalase
B
Superoxide Dismutase
C
NADPH oxidase
D
Glutathione peroxidase
High-Yield Explanation
Ans. (c) NADPH oxidase(Ref: R 9th/pg 48; 8th/pg 13,14)AntioxidantsEnzymesNon enzymes* Catalase- Present in peroxisomes Q decomposes H2 O2 Antioxidants- vitamins E, A and C glutathione in the cytosol.*. Superoxidase dismutases: O2- to H2 O2 *. Manganese-SOD, which is localized in mitochondria,*. Copper-zinc-SOD, which is found in the cytosol.Transferrin, ferritin, lactoferrin, and ceruloplasmin Q - Minimise the reactivity of metals by binding with themGlutathione peroxidase: H2 O2 +2GSH-GSSG+2H2 O*. Important indicator of the cell's ability to detoxify ROSQNADPH oxidaseOxidizes NADPH Q (reduced nicotinamide-adenine dinucleotide phosphate) and, in the process, reduces oxygen to superoxide. Q

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