Jarisch - Herxheimer reaction are seen in syphilis With

(Penicillin) (657-KDT) (698-KDT 6th)Jerisch-Herxheimer reaction:- Penicillin injected in a syphilitic patient (particularly secondary syphilis) may produce shivering, fever myalgia, exacerbation of lesions, even vascular collapse. This is due to sudden release of spirochetal lytic products and lasts 12-72 hours. It does not recur and does not need interruption of therapy.Aspirin and sedation afford relief of symptoms.