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General Medicine General 81ad349a

A 15-year-old boy is subjected to recurrent attacks of asthma. A careful clinical history reveals that the asthma attacks occur most frequently after aspirin administration. Which of the following is the pathogenetic mechanism in this form of asthma?

A
Direct release of bronchoconstrictor mediators
B
Enhanced sensitivity to vagal stimulation
C
Inhibition of cyclooxygenase pathway
D
Type I hypersensitivity reaction
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