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Biochemistry General 802d86ed

Irreversible step in citric acid cycle is catalyzed by ?

A
Aconitase
B
Succinate thiokinase
C
a-ketoglutarate dehydrogenase
D
Isocitrate dehydrogenase
High-Yield Explanation
Ans. is 'c' i.e., a-ketoglutarate dehydrogenase There are two irreversible steps :oxaloacetate to citrate catalysed by citrate (synthase), anda-ketoglutarate to succinyl CoA, catalyzed by a-ketoglutarate dehydrogenase.

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