A 25-year-old female presented to the OPD with painless cervical lymphadenopathy for 2 months. On examination the lymph nodes were firm in consistency. Epitrochlear lymph nodes were also involved. There was also history of fever, night sweats and significant weight loss. A lymph node biopsy was conducted and sent for HPE examination. Flow cytometry studies were also done. Which of the following gene is involved in the above condition: -
High-Yield Explanation
This is a case of follicular lymphoma. The normal nodal architecture is effaced It is effaced by nodular expansions of tumor cells. Nodules predominantly small lymphocytes with cleaved nuclei Also, we see larger cells with vesicular chromatin and prominent nucleoli. It is CD19, CD20, CD10 and BCL6 positive, and CD5 and CD23 negative. t(14:18) is present Mutation of BCL-2 is seen