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Pediatrics Genetic and genetic disorders 7e183363

Down Syndrome, All are seen except

A
t (14 ; 21)
B
Trisomy 21
C
t (11:14)
D
t (15:21)
High-Yield Explanation
Majority of translocations in Down syndrome are fusions at the centromere between chromosomes 13,14,15,21 and 22.These are known as Robeson I an translocation. t(11:14 ) is not seen in down syndrome. Reference : Nelson TB of pediatrics 19th edition pg 402.

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