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Pathology NEET 2019 7e0eae85

Caspase involved in activation of IL_1 is which of the following?

A
Caspase 1
B
Caspase 3
C
Caspase 5
D
Caspase 8
High-Yield Explanation
Pyroptosis :- Example of process in which injury is initiated because of exposure to microbes. Whenever there is exposure to microbes there is activation of enzyme caspase 1 and caspase 11. Caspase 1 conve inactive form of IL 1 to active form of IL1. As IL1 has central action, it enters CNS and results in development of fever. Caspase-1 along with closely related caspase-11 also cause death of the infected cell. -Caspase 3, a typical executioner caspase that cleaves DNA and other substrates to cause cell death.

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