CIN III progresses to carcinoma in how many % of cases:

CIN: Cervical intraepithelial neoplasia-part or whole of thickness of cervical squamous epithelium is replaced by cell of varying degress of atypia CIN: Microinvasive carcinoma- invasive carcinoma cervix (over several years) Mostly asymptomatic, diagnosed by routine screening done yearly after a women become sexually active. If 3 consecutive smears normal in a low risk woman do once in 3 years CIN I-Abnormality in lower 1/3rd of epithelium CIN II-Abnormality in lower 2/3rd of epithelium CIN III-Abnormality in >2/3rd of epithelium High risk factor--­ Age <18 yr at initiation of coitus Multiple sex partners, husband with multiple parteners HPV infection High oncogenic risk-type 16, 18, 31, 45, 56 Low oncogenic risk-type 6, 11 CMV, HSV II infection Smoking Poor socioeconomic status Aneuploid lesion Oral contraceptive use.