Full 2L QBank
Biochemistry General 7be92246

Why does decreased glycolytic activity impair oxygen transpo by hemoglobin?

A
Due to reduced energy production
B
Due to decreased production of 2,3-bisphosphoglycerate
C
Due to reduced synthesis of hemoglobin at low levels of oxygen
D
None of the above
High-Yield Explanation
2,3-Bisphosphoglycerate (2,3-BPG) is the most abundant organic phosphate in the erythrocytes. It is produced in the erythrocytes from an intermediate (1,3-biphosphoglycerate) of glycolysis. This sho pathway is called Rapapo-Leubering cycle. It normally binds to hemoglobin and decrease it's affinity to oxygen and thereby helps in oxygen delivery. When glycolytic activity is reduced, oxygen transpo by hemoglobin is impaired due to decreased production of 2,3 BPG. In hypoxia and anemia 2,3-BPG in the erythrocytes is elevated. Ref: Essentials of Biochemistry, Satyanarayanan, Page 108

Related Biochemistry MCQs

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now