Siuin is associated with ?

Calorie restriction prolongs lifespan and this longevity appears to be mediated by a family of proteins known as siuin.They have histone deacetylase activity.Red wine can activate siuins and thus increase lifespan. Actions of siuins:- Siuins promote the expression of many genes which increase longevity. The proteins products of these genes increase metabolic activity, reduce apoptosis, stimulate protein folding and inhibit the damaging effects of oxygen-free radicals. Siuins also increase insulin sensitivity and glucose metabolism.