Which of the following is the drug of choice for the treatment of inappropriate anti-diuretic hormone secretion -
High-Yield Explanation
Chronic SIADH is best treated by oral fluid restriction. In young children,this degree of fluid restriction might not provide adequate calories for growth. In this situation, the creation of nephrogenic diabetes insipidus using demeclocycline therapy may be indicated to allow sufficient fluid intake for normal growth. Page 1886, Nelson Textbook of Pediatrics