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Microbiology Immunology 7af55ee1

Which of the following does not describe a documented mechanism of tumor-mediated immune evasion?

A
Down regulation of class I MHC
B
Secretion of TGF-b
C
Secretion of decoy molecules
D
Antigenic variation
High-Yield Explanation
Tumor cells have evolved mechanisms to escape and evade immune recognition. These mechanisms include various molecular genetic processes of eliminating MHC I from the tumor cell surface. Mutations inhibit efficient antigen processing and presentation. Tumor cells also block immune cells by secretion of suppressor proteins, most commonly TGF-b1, and other cytokine like "decoy" molecules to confuse the immune system. Antigenic variation is an immune escape mechanism ascribed to pathogenic microbes such as viruses for example.

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