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Pharmacology General 7a96acdd

The mechanism of action of sodium nitroprusside is?

A
Increased cAMP
B
Increased guanylate cyclase
C
Calcium channel blockage
D
IC channel opener
High-Yield Explanation
Ans. is 'b' i.e., Increases Guanyl Cyclase o "Nitroprusside dilates both aerial and venous vessels, resulting in reduced peripheral vascular resistance and venous return. The action occurs as a result of activation of guanylyl cyclase, either release of nitric oxide or by direct stimulation of enzyme. The result is increased intracellular cGMP, which relaxes vascular smooth muscle".

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