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Microbiology General 7a7bdfa9

All of the following statement are true regarding CNS infection, except :

A
Measles virus is causative agent of subacute sclerosing panencephalitis
B
Cytomegalo virus causes bilateral temporal lobe hemorrhagic infarction
C
Prion infection causes spongiform encephalopathy
D
JC virus is causative agent of progressive multifocal leukoencephalopathy
High-Yield Explanation
CNS manifestation of CMV : – CMV rarely cause CNS infection. – Two forms of CMV encephalitis are seen : Resemble HIV encephalitis and present as progressive dementia. Ventriculoencephalitis - Characterized by cranial nerve deficit, nystagmus and ventriculomegaly. – In immunocompromised patient, CMV can also cause subacute progressive polyradiculopathy. Nowhere is given that CMV can cause temporal lobe infarction : Hence answer is OPTION 2 Other options : Subacute sclerosing pan encephalitis: – It is a rare chronic progressive demyelinating disease of CNS associated with a chronic permissive infection of brain tissue with measles virus. Progressive Multifocal leucoencephalopathy: – Progressive disorder characterised pathologically by multifocal areas of demyelination of varying size distributing throughout the CNS caused by JC virus. Spongiform encephalopathy: – Caused by prion infection; HIV infection.

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